abstract：:Phospholipase D (PLD) plays a central role in receptor-mediated breakdown of choline phospholipids and formation of phosphatidic acid (PA), an important regulator of cardiac function. However, specific mechanisms that regulate myocardial PLD activity remain largely unknown, particularly in the human heart. We hypothes...

journal_title：Journal of molecular and cellular cardiology

authors： Kurz T,Kemken D,Mier K,Weber I,Richardt G

更新日期：2004-02-01 00:00:00

abstract：:In recently published studies, we show that angiotensin II (AII) generated from an engineered rat angiotensinogen cDNA, and maintained intracellularly, is growth stimulatory for a rat hepatoma cell line. In the present study, we report that co-expression of AII fused to cyan fluorescent protein (ECFP/AII) and angioten...

journal_title：Journal of molecular and cellular cardiology

authors： Cook JL,Re R,Alam J,Hart M,Zhang Z

更新日期：2004-01-01 00:00:00

abstract：:Diabetic cardiomyopathy is responsible for substantial morbidity and mortality in the diabetic population. Increased oxidative stress has been associated with the pathogenesis of chronic diabetic complications including cardiomyopathy. Multiple biochemical mechanisms have been proposed to increase oxidative stress in ...

journal_title：Journal of molecular and cellular cardiology

authors： Farhangkhoee H,Khan ZA,Mukherjee S,Cukiernik M,Barbin YP,Karmazyn M,Chakrabarti S

更新日期：2003-12-01 00:00:00

abstract：:Recent observations challenged the functional importance or even the existence of mitochondrial ATP-dependent K+ (mitoK(ATP)) channels. In the present study, we determined the presence of K(ATP)-channel subunits in mouse heart mitochondria, and investigated whether known openers or blockers of the channel can alter mi...

journal_title：Journal of molecular and cellular cardiology

authors： Lacza Z,Snipes JA,Miller AW,Szabó C,Grover G,Busija DW

更新日期：2003-11-01 00:00:00

abstract：:We recently showed that angiotensin (ANG) II as well as mechanical stretch stimulated production of tumor necrosis factor (TNF) in cardiac fibroblasts. Presently, we examined the molecular mechanisms by which ANGII and lipopolysaccharide (LPS) upregulate TNF-alpha gene expression. In neonatal rat cardiac fibroblasts, ...

journal_title：Journal of molecular and cellular cardiology

authors： Sato H,Watanabe A,Tanaka T,Koitabashi N,Arai M,Kurabayashi M,Yokoyama T

更新日期：2003-10-01 00:00:00

abstract：:Satellite cells from adult mouse tongue, diaphragm, vastus lateralis, rectus femoris, tibialis anterior, soleus, and extensor digitorum longus muscles were isolated, expanded, and differentiated under identical culture conditions. Proliferating myoblasts and differentiated myofiber cultures were analyzed via SDS-PAGE,...

journal_title：Journal of molecular and cellular cardiology

authors： LaFramboise WA,Guthrie RD,Scalise D,Elborne V,Bombach KL,Armanious CS,Magovern JA

更新日期：2003-10-01 00:00:00

abstract：:The Ca(2+)-independent, voltage-gated transient outward current (I(to)) displays a marked increase during development of cardiomyocytes. However, the molecular mechanism remained unclear. In rat adult ventricular myocytes, I(to) can be divided into a fast (I(to,f)) and a slow (I(to,s)) component by recovery process fr...

journal_title：Journal of molecular and cellular cardiology

authors： Kobayashi T,Yamada Y,Nagashima M,Seki S,Tsutsuura M,Ito Y,Sakuma I,Hamada H,Abe T,Tohse N

更新日期：2003-09-01 00:00:00

abstract：:Patients with chronic coronary artery disease may exhibit chronically depressed regional myocardial function, which can be reversed by revascularization. This was called hibernating myocardium, since it was thought that myocardial blood flow was also chronically reduced and since animals during true hibernation are th...

journal_title：Journal of molecular and cellular cardiology

authors： Kudej RK,Vatner SF

更新日期：2003-08-01 00:00:00

abstract：:A number of endogenous mediators, including opioids, adenosine and bradykinin, which act on cardiac cell membrane receptors have been demonstrated to trigger the phenomenon termed ischemic preconditioning (IPC). IPC is an endogenous protective mechanism, whereby a brief period of ischemia or hypoxia protects a cell or...

journal_title：Journal of molecular and cellular cardiology

authors： Gross GJ

更新日期：2003-07-01 00:00:00

abstract：:Transposition of great arteries in humans is associated with a wide spectrum of coronary artery patterns. However, no information is available about how this pattern diversity develops. We have studied the development of the coronary arteries in mouse embryos with a targeted mutation of perlecan, a mutation that leads...

journal_title：Journal of molecular and cellular cardiology

authors： González-Iriarte M,Carmona R,Pérez-Pomares JM,Macías D,Costell M,Muñoz-Chápuli R

更新日期：2003-07-01 00:00:00

abstract：:Mutations causing familial hypertrophic cardiomyopathy (HCM) have been described in at least 11 genes encoding cardiac sarcomeric proteins. In this study, three previously unknown deletions have been identified in the human cardiac genes coding for beta-myosin heavy chain (MYH7 on chromosome 14) and myosin-binding pro...

journal_title：Journal of molecular and cellular cardiology

authors： Waldmüller S,Sakthivel S,Saadi AV,Selignow C,Rakesh PG,Golubenko M,Joseph PK,Padmakumar R,Richard P,Schwartz K,Tharakan JM,Rajamanickam C,Vosberg HP

更新日期：2003-06-01 00:00:00

abstract：:The mechanisms by which beta-adrenergic receptor (beta-AR) blockade modulates apoptosis in heart failure (HF) are unclear. We examined the impact of beta-AR blockade with metoprolol on myocardial remodeling, apoptosis, pro-apoptotic (Fas, Fas ligand, Bax, and Bcl-X(S)) and anti-apoptotic (Bcl-X(L)and Bcl-2) gene expre...

journal_title：Journal of molecular and cellular cardiology

authors： Prabhu SD,Wang G,Luo J,Gu Y,Ping P,Chandrasekar B

更新日期：2003-05-01 00:00:00

abstract：:Andersen's syndrome (AS) (which is characterized by periodic paralysis, cardiac arrhythmias and dysmorphic features), a hereditary disease, and missense mutations of KCNJ2 (which encodes an inward rectifying potassium channel) have been reported recently. We performed clinical and molecular analyses of a patient with ...

journal_title：Journal of molecular and cellular cardiology

authors： Hosaka Y,Hanawa H,Washizuka T,Chinushi M,Yamashita F,Yoshida T,Komura S,Watanabe H,Aizawa Y

更新日期：2003-04-01 00:00:00

abstract：:Sensitive to apoptosis gene (SAG) is a novel RING finger protein that has been shown to be involved in protection against apoptotic cell death induced by oxidative stress in various cell types. As SAG has been previously shown to be expressed in the heart, we assessed its role in cardiac myocytes exposed to ischaemic ...

journal_title：Journal of molecular and cellular cardiology

authors： Chanalaris A,Sun Y,Latchman DS,Stephanou A

更新日期：2003-03-01 00:00:00

abstract：:To investigate the interaction of cytoskeleton with the receptor modulation of ionic currents, we studied the effect of muscarinic and beta-adrenergic stimulation in adult guinea-pig ventricular cardiac myocytes treated with paclitaxel and colchicine, two drugs that respectively stabilize or destabilize microtubules. ...

journal_title：Journal of molecular and cellular cardiology

authors： Malan D,Gallo MP,Bedendi I,Biasin C,Levi RC,Alloatti G

更新日期：2003-02-01 00:00:00

abstract：:The Gq-RhoA-Rho kinase pathway, activated by neurohormonal factors such as angiotensin II (Ang II), has been proposed to be one of the important signaling pathways involved in the progression of left ventricular (LV) hypertrophy to heart failure. We tested the hypothesis that chronic inhibition of Rho kinase prevents ...

journal_title：Journal of molecular and cellular cardiology

authors： Satoh S,Ueda Y,Koyanagi M,Kadokami T,Sugano M,Yoshikawa Y,Makino N

更新日期：2003-01-01 00:00:00

abstract：:Oxidative stress markedly alters protein function through redox modification of sulfhydryl groups present in cysteine residues. To explore the role of redox state in modulating cardiac K+ channels, this study examined the effects of sulfhydryl modifiers on the repolarizing transient outward current (Ito) in voltage-cl...

journal_title：Journal of molecular and cellular cardiology

authors： Rozanski GJ,Xu Z

更新日期：2002-12-01 00:00:00

abstract：:Increasing evidence suggests that derangements of cytoskeletal proteins contribute to alterations in intracellular signaling, myocyte function, and the coupling of myocytes to the extracellular matrix during cardiac hypertrophy and failure. Data from animal studies have shown an increased density of beta-tubulin prote...

journal_title：Journal of molecular and cellular cardiology

authors： Aquila-Pastir LA,DiPaola NR,Matteo RG,Smedira NG,McCarthy PM,Moravec CS

更新日期：2002-11-01 00:00:00

abstract：:The activation of vascular smooth muscle cells (SMCs) in neointimal hyperplasia involves signaling through receptor tyrosine kinases as well as G protein-coupled receptors. Overexpression of G protein-coupled receptor kinase-2 (GRK2) in SMCs can attenuate mitogenic signaling and proliferation in response to not only s...

journal_title：Journal of molecular and cellular cardiology

authors： Peppel K,Zhang L,Huynh TT,Huang X,Jacobson A,Brian L,Exum ST,Hagen PO,Freedman NJ

更新日期：2002-10-01 00:00:00

abstract：:The concept of metabolic protection of the ischemic myocardium is in constant evolution and has recently been supported by clinical studies. Historically, enhanced glucose metabolism and glycolysis were proposed as anti-ischemic cardioprotection. This hypothesis is supported by the sub-cellular linkage between key gly...

journal_title：Journal of molecular and cellular cardiology

authors： Opie LH,Sack MN

更新日期：2002-09-01 00:00:00

abstract：:It has recently been proposed that the Ca(2+) uptake by the SR is inhibited by blocking Cl(-) and/or K(+) movements across this intracellular membrane. We have characterised the functional and pharmacological profile of the SR K(+) channel derived from human and sheep atrial cells. Mammalian atrial SR preparations wer...

journal_title：Journal of molecular and cellular cardiology

authors： Picard L,Côté K,Teijeira J,Greentree D,Rousseau E

更新日期：2002-09-01 00:00:00

abstract：:Cardiac alpha(1)-adrenoceptors (AR) have two predominant subtypes (alpha(1A)-AR and alpha(1B)-AR) however, their roles in regulating contraction are unclear. We determined the effects of stimulating alpha(1A)-AR (using the subtype-selective agonist A61603) and alpha(1B)-AR (using a gene knockout mouse lacking alpha(1A...

journal_title：Journal of molecular and cellular cardiology

authors： McCloskey DT,Rokosh DG,O'Connell TD,Keung EC,Simpson PC,Baker AJ

更新日期：2002-08-01 00:00:00

abstract：:Nkx2.5 and serum response factor (SRF) are critically important transcription factors in cardiac morphogenesis. They are also widely expressed in adult cardiomyocytes, but there is little data to indicate their possible role in adult cardiac cells. In this paper we demonstrate that the interaction of Nkx2.5 and SRF in...

journal_title：Journal of molecular and cellular cardiology

authors： Müller JG,Thompson JT,Edmonson AM,Rackley MS,Kasahara H,Izumo S,McQuinn TC,Menick DR,O'Brien TX

更新日期：2002-07-01 00:00:00

abstract：:Myocarditis triggered by a viral infection has integral viral and immunological aspects associated with the pathogenesis of disease. The present study was performed to analyse the cellular inflammatory response in the heart and cytomegalovirus replication during the development of myocarditis in vivo. We examined muri...

journal_title：Journal of molecular and cellular cardiology

authors： Lenzo JC,Fairweather D,Cull V,Shellam GR,James Lawson CM

更新日期：2002-06-01 00:00:00

abstract：:Mitochondrial adenine nucleotide translocase (ANT) is a specific target for the autoantibody response in idiopathic dilated cardiomyopathy (IDCM). We have undertaken an epitope analysis of ANT in IDCM by immunoblot with recombinant GST-ANT fusion proteins and with cellulose-bound decapeptides of human ANT1. Forty-five...

journal_title：Journal of molecular and cellular cardiology

authors： Manchado C,Orús J,Villarroya F,Roig E,Heras M,Giralt M,Iglesias R,Sanz G,Mampel T,Viñas O

更新日期：2002-05-01 00:00:00

abstract：:Effects of ischemia time and treatment interventions upon troponin I (TnI) proteolysis and function of reperfused myocardium were examined in isolated, perfused rabbit hearts. Hearts were randomized to 90 min aerobic perfusion, 15 min low-flow (1 ml/min) ischemia (I) and 60 min reperfusion (R) or 60 min low-flow I and...

journal_title：Journal of molecular and cellular cardiology

authors： Prasan AM,McCarron HC,Hambly BD,Fermanis GG,Sullivan DR,Jeremy RW

更新日期：2002-04-01 00:00:00

abstract：:Activation of adenosine A(3) receptor (A(3)AR) protects against ischemia/reperfusion injury in the heart. However, the downstream signaling mechanisms leading to its delayed anti-ischemic effects remain unclear. We hypothesized that A(3)AR stimulation protects the heart via activation of nuclear transcription factor k...

journal_title：Journal of molecular and cellular cardiology

authors： Zhao TC,Kukreja RC

更新日期：2002-03-01 00:00:00

abstract：:Introduced several decades ago, the dogma persists that ventricular myocytes are terminally differentiated cells and cardiac repair by myocyte regeneration is completely inhibited shortly after birth. On the basis that cardiac myocytes are unable to divide in the adult heart, myocyte growth under physiologic and patho...

journal_title：Journal of molecular and cellular cardiology

authors： Anversa P,Leri A,Kajstura J,Nadal-Ginard B

更新日期：2002-02-01 00:00:00

abstract：:Chemokines are small molecular weight proteins that play important roles in inflammation. Originally described as chemotactic cytokines, chemokines stimulate the influx of leukocytes into specific tissue compartments. These molecules also modulate gene expression in both infiltrating and resident cells to mediate a va...

journal_title：Journal of molecular and cellular cardiology

authors： Tarzami ST,Cheng R,Miao W,Kitsis RN,Berman JW

更新日期：2002-02-01 00:00:00

abstract：:Recent evidence has shown that the cardioprotection afforded by the late phase of ischemic preconditioning (PC) is mediated by upregulation of inducible nitric oxide synthase (iNOS). However, the specific cardiac cell type(s) that express(es) iNOS in response to ischemic PC remains unknown. Thus, mice underwent a sequ...

journal_title：Journal of molecular and cellular cardiology

authors： Wang Y,Guo Y,Zhang SX,Wu WJ,Wang J,Bao W,Bolli R

更新日期：2002-01-01 00:00:00

abstract：:Our previous work in cultured cells has shown that the maintenance of mitochondrial Ca(2+) homeostasis is essential for cell survival, and that the anti-apoptotic protein Bcl-2 is able to maintain a threshold level of mitochondrial Ca(2+) by the inhibition of permeability transition. To test whether Bcl-2 also affects...

journal_title：Journal of molecular and cellular cardiology

authors： Zhu L,Yu Y,Chua BH,Ho YS,Kuo TH

更新日期：2001-12-01 00:00:00

abstract：:The 23Na NMR shift-reagent complexes (Dy(PPP)2, Dy(TTHA), and Tm(DOTP)) bind stoichiometric amounts of Ca2+. Thus, in perfused rat heart systems, a supplementation of Ca2+ is required to maintain the requisite extracellular free calcium concentration ([Ca(o)]f) and to approximate a physiological level of contractile f...

journal_title：Journal of molecular and cellular cardiology

authors： Gaszner B,Simor T,Hild G,Elgavish GA

更新日期：2001-11-01 00:00:00

abstract：:The progression of cardiomyopathy to congestive heart failure is often associated with the expression of fetal cardiac-specific genes. In mice, the basic helix-loop-helix transcription factors, dHAND and eHAND, are expressed in a cardiac chamber-specific fashion and are essential for fetal cardiac development, but are...

journal_title：Journal of molecular and cellular cardiology

authors： Natarajan A,Yamagishi H,Ahmad F,Li D,Roberts R,Matsuoka R,Hill S,Srivastava D

更新日期：2001-09-01 00:00:00

abstract：:Diabetes and hypertension both produce myocardial dysfunction that accelerates cardiovascular morbidity and mortality. Coexistence of the two often results in a more severe cardiomyopathy than either process alone. The purpose of this study was to characterize the contractile function of diabetic hypertensive cardiomy...

journal_title：Journal of molecular and cellular cardiology

authors： Wold LE,Relling DP,Colligan PB,Scott GI,Hintz KK,Ren BH,Epstein PN,Ren J

更新日期：2001-09-01 00:00:00

abstract：:Targeted expression of the SV40 large T-antigen oncoprotein (T-Ag) induces cardiomyocyte proliferation in the atria and ventricles of transgenic mice. Previous studies have identified the p53 tumor suppressor, p107 (a homologue of the retinoblastoma tumor suppressor), and p193 (a novel BH3 only proapoptosis protein) a...

journal_title：Journal of molecular and cellular cardiology

authors： Huh NE,Pasumarthi KB,Soonpaa MH,Jing S,Patton B,Field LJ

更新日期：2001-08-01 00:00:00

abstract：:Short duration exposure to cellular stresses have been shown to activate p38 mitogen-activated protein kinase (MAPK) in cultured rat ventricular cardiomyocytes and isolated perfused hearts; however, effects of chronic stress on p38 MAPK are not well understood. This study determined whether alterations in the p38 MAPK...

journal_title：Journal of molecular and cellular cardiology

authors： Lemke LE,Bloem LJ,Fouts R,Esterman M,Sandusky G,Vlahos CJ

更新日期：2001-08-01 00:00:00

abstract：:Gender has recently been implicated as an important modulator of cardiovascular disease. However, it is not known how gender may specifically influence the Ca2+-handling deficits that characterize the depressed cardiac contractility of human heart failure. To elucidate the contributory role of gender to sarcoplasmic r...

journal_title：Journal of molecular and cellular cardiology

authors： Dash R,Frank KF,Carr AN,Moravec CS,Kranias EG

更新日期：2001-07-01 00:00:00

abstract：:Congenital heart block (CHB) affects offspring of mothers with autoantibodies (positive IgG) to intracellular SSA/Ro and SSB/La ribonucleoproteins and is associated with high morbidity and mortality. Here, we show that maternal anti-Ro/La antibodies immunoreact with human fetal cardiomyocyte sarcolemma, recognize huma...

journal_title：Journal of molecular and cellular cardiology

authors： Qu Y,Xiao GQ,Chen L,Boutjdir M

更新日期：2001-06-01 00:00:00

abstract：:Left ventricular hypertrophy may lead to heart failure. The transition between hypertrophy and heart failure is, however, incompletely understood. On the cellular level, human heart failure is characterized by alterations in Ca(2+)-cycling proteins and beta-adrenergic receptor density, but the hypertrophied human hear...

journal_title：Journal of molecular and cellular cardiology

authors： DiPaola NR,Sweet WE,Stull LB,Francis GS,Schomisch Moravec C

更新日期：2001-06-01 00:00:00

abstract：:G. Y. Oudit, Z. Kassiri, R. Sah, R. J. Ramirez, C. Zobel and P. H. Backx. The Molecular Physiology of the Cardiac Transient Outward Potassium Current (I(to)) in Normal and Diseased Myocardium. Journal of Molecular and Cellular Cardiology (2001) 33, 851-872. The Ca(2+)-independent transient outward potassium current (I...

journal_title：Journal of molecular and cellular cardiology

authors： Oudit GY,Kassiri Z,Sah R,Ramirez RJ,Zobel C,Backx PH

更新日期：2001-05-01 00:00:00